Because Lp(a) is genetically determined, elevated levels often occur among multiple family members. A single blood test in one parent can therefore be a reason to test children, siblings, or other close relatives as well. Knowing early helps prevent cardiovascular risks later in life.

Family screening (cascade testing)

Family screening for Lp(a) — also called cascade testing — involves testing family members of someone who has an elevated Lp(a) level. This approach allows doctors to identify hereditary cardiovascular risks at an early stage, often before symptoms or damage occur. By testing children or adolescents in families with known elevated Lp(a), preventive steps such as monitoring cholesterol, encouraging healthy habits, and educating about long-term heart health can start early.

When should children be tested for Lp(a)?

Testing children for Lp(a) is advisable in the following situations:

• When a parent or grandparent has elevated Lp(a) levels.
• In cases of unexplained high cholesterol or early-onset heart problems in the family.
• On the recommendation of a pediatrician, internist, or cardiologist.

How the test works

An Lp(a) blood test can easily be performed at home using a certified home test or through your general practitioner with a laboratory blood draw. In both cases, the sample is analyzed in a medically accredited laboratory to ensure accurate and reliable results. The test requires only a small blood sample and is often combined with a standard cholesterol panel. Since your Lp(a) level is genetically determined and remains stable throughout life, one test is sufficient to map your genetic cardiovascular risk.

Sources
Scientific sources and medical references. The information on this page about lipoprotein(a), genetic inheritance, family screening (cascade screening), and testing in children is based on reliable medical and scientific sources.

• Erasmus MC – Information and research on lipoprotein(a) and hereditary cardiovascular risk
  https://www.erasmusmc.nl/nl-nl/patientenzorg/aandoeningen/lipoproteine-a

• Dutch Heart Foundation (Hartstichting) – Genetic factors, cholesterol, and cardiovascular disease
  https://www.hartstichting.nl/hart-en-vaatziekten/erfelijkheid

• European Heart Journal (2023) – Scientific publications on lipoprotein(a), genetic screening, and cardiovascular risk
  https://academic.oup.com/eurheartj/article/44/24/2231/7174788

• UMC Utrecht – Familial screening and hereditary cardiovascular diseases
  https://www.umcutrecht.nl/nl/ziekenhuis/behandelingen/familiaire-hypercholesterolemie

• Dutch Heart Foundation (Hartstichting) – Cholesterol testing and blood analysis
  https://www.hartstichting.nl/hart-en-vaatziekten/cholesterol

The information on this page is intended for educational purposes only and does not replace personal medical advice. Always consult a general practitioner or medical specialist if you have questions or concerns.